Teva, Intel collaborate to develop machine learning platform And wearable tech for Huntington disease

• Jerusalem : Teva Pharmaceutical Industries Ltd., announced a collaboration with Intel Corporation to develop a unique wearable device and machine learning platform for use in Huntington disease (HD). This platform will continuously monitor and analyze key symptoms that impact daily living, in an effort to better understand disease progression and improve treatment evaluation.
• Teva, working in collaboration with Intel, will deploy this novel technology platform for the first time in a sub-study within the ongoing phase 2 Open-Pride HD Study. As part of this, patients will be asked to use a smartphone and wear a smartwatch equipped with sensing technology that will continuously measure their general functioning and movement. These data will be wirelessly streamed to a cloud-based platform specifically developed by Intel to analyze data from wearable devices. Proprietary algorithms will then translate these data, in near real-time, into objective scores of motor symptom severity. The study will start towards the end of the year and will take place in centers in the US and Canada.
• This collaboration will leverage Intel's capabilities in analytics and algorithm development for movement detection, together with Teva's deep knowledge and experience in HD treatment and research. HD is a devastating illness that is desperate for treatment options, requiring innovative ways to continuously and remotely assess and quantify symptoms in a way that can provide meaningful and actionable feedback to doctors, patients and caregivers.
• "The aim of this important project is to provide continuous objective data on the impact of Huntington disease on the patient, and, by extension, a clear understanding of the impact of treatment on patients' quality of life," said Michael Hayden, president of Teva Global R&D and chief scientific officer. "Current measurement of symptoms is largely based on observation when the patient sees the doctor. This technology now provides us with an opportunity to have continuous monitoring. This unique technology could complement future trials in HD."
• “Patients generate data based on their day-to-day experiences that can help in improving disease management — even something as simple as wearing a smart watch can add useful insight,” said Jason Waxman, corporate vice president and general manager of the Datacenter Solutions Group at Intel. “The complexity of analyzing these data streams requires a platform for machine learning, to help drive the pharmaceutical industry towards faster, better clinical trials, potentially leading to new treatments for patients.”
• This cloud-based solution for analyzing wearable device data is being developed using the open-source Intel Trusted Analytics Platform (TAP), a software platform optimized for performance and security to accelerate the creation of advanced analytics and machine learning solutions. Initial development was done in collaboration with The Michael J. Fox Foundation for use in Parkinson's disease research.
• Huntington disease (HD) is a fatal neurodegenerative disease characterized by uncoordinated and uncontrollable movements, cognitive deterioration and behavioral and/or psychological problems. The classic onset of HD symptoms typically occurs in middle age, but the disease also manifests in children and the elderly. HD is the most common genetic cause of abnormal involuntary writhing movements called chorea. Disease progression is characterized by a gradual decline in motor control, cognition and mental stability and generally results in death within 15-25 years of clinical diagnosis.
• HD is a genetic disease, passed from parent to child through a gene mutation. Each child of an HD parent has a 50-50 chance of inheriting the HD gene. If a child does not inherit the HD gene, he or she will not develop the disease and cannot pass it to subsequent generations. A person who inherits the HD gene will sooner or later develop the disease. According to the World Health Organization, Huntington disease affects about five to seven people per 100,000 in Western countries.

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