Cadmium (Cd) is a toxic and non-essential heavy metal. The present study is carried out to know the protective effect of zinc (Zn) and vitamin C supplementation against Cd induced bioaccumulation in liver and kidney of Cd treated rats. Male wistar albino rats were treated with cadmium chloride(CdCl2) at a dose of 1/10th LD50/ 48h i.e. 22.5 mg/Kg body weight for 7, 15 and 30 days (d) time intervals. Then 15 d Cd treated rats were divided into three groups. The first group received Zn (12 mg/Kg), second group received vitamin C (200 mg/Kg) alone and third group supplemented with both Zn and vitamin C again for 7, 15 and 30 d long sojourn. After specific time intervals, rats were decapitated and tested for Cd bioaccumulation by Atomic Absorption Spectrophotometer (AAS).
There was a significant elevation in Cd levels in both the tested tissues with increased period of Cd treatment. Maximum Cd accumulation was found in 30 d Cd treated rat kidney (42.80 ± 0.30 μg /gm wet wt. of the tissue). Maximum decrease in Cd accumulation was found in 30 d treated rat kidney (5.04 ± 0.08μg / gm wet wt. of the tissue) supplemented with the combination of Zn and vitamin C. Our findings clearly indicates that combined supplementation of Zn and vitamin C is more effective in reducing the Cd body burden when compared to the other modes of supplementation i.e. Zn and vitamin C alone in the male albino rat.
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