Amoxicillin (amox), also spelled amoxycillin, is an antibiotic useful for the treatment of a number of bacterial infections. It is the first line treatment for middle ear infections. It may also be used for strep throat, pneumonia, skin infections, and urinary tract infections among others. It is taken by mouth.

Amoxicillin first became available in 1972. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is one of the most commonly prescribed antibiotics in children.