1.0 PURPOSE:
To describe a standard operating procedure (SOP) for vacuum distillation.
2.0 SCOPE:
The SOP describes in detail the method of vacuum distillation.
3.0 RESPONSIBILITY:
The responsibility of carrying out vacuum distillation as per the SOP lies with the staff of rank not lower than operator of production department.
The responsibility of preparing, reviewing and approving the SOP lies with the Officer (Production), Head of Production and Head of QAD respectively.
4.0 METHOD:
4.1 Close the distillation line vent valve, open the condenser chilled water valves.
4.2 Apply vacuum slowly to reach the higher limit of desired vacuum range.
4.3. Close the jacket inlet valve and drain valve. Open the steam trap valve.
4.4. Connect the jacket outline hose pipe to steam line valve.
4.5. Open steam valve slowly. When the temperature of the reaction mass reaches 5 degree C. below the lower limit of desired temperature range, close the steam valve and observe the rise in temperature.
4.6. Continue distillation in the specified range of vacuum and desired range of temperature.
5.0 RECORDING:
The vacuum distillation operation will be recorded by the operator/supervisor in the temperature cum vacuum record attached to the batch manufacturing sheet.
Production, vacuum distillation
