img

Guaifenesin

Guaifenesin INN or guaiphenesin, also glyceryl guaiacolate, is an expectorant drug sold over the counter and usually taken orally to assist the bringing up of phlegm from the airways in acute respiratory tract infections. More

Sharing is caring, show love and share the thread with your friends.

Description

Guaifenesin INN or guaiphenesin, also glyceryl guaiacolate, is an expectorant drug sold over the counter and usually taken orally to assist the bringing up of phlegm from the airways in acute respiratory tract infections.

Generic Name

Guaifenesin

Chemical names

Guaifenesin; 93-14-1; Guaiphenesin; Glycerol guaiacolate; Guaiphenesine

Brand names

Abcof, Altec, Ambrex, Ambro-AB, Ambrokof, Anbrox, Arony, Ascordyl, Ascoril, Ascoril Exp, Asi-Ril, Ategua, Avicof-X, Barkeit, Berikof-L, Biokof, Biozara, Bro-Exces, Brodex Exp, Brodin-LS, Brofentol, Brofentol Plus, Bronsim, Brony, Browin Jun Exp, Browin-TG Exp, Celepid Mct-Lct, Cepticof-P, Codylex Exp, Codylex-PD Exp, Cofree, Cufokin, Dexen, Dextrol, Expect-D, Expect-T, Fine-O, Grilinctus, Indikof-B, Jdcold, Jetrex, Jilosyn, Jilosyn-DS, Kickkof, Kofban-EX, Lincotus-Ex, M&B, Macbery-XT, Megaril, Mucaryl-Ax EXP

IUPAC name

3-(2-methoxyphenoxy) propane-1, 2-diol

Pharmacokinetics

NA

Actions

Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing the surface tension and.adhesiveness By reducing the adhesiveness of secretions and viscosity, this drug increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.

Dosage/Dosage form

PO- The recommended dose is 200 to 400 mg 4 hourly. Max: 2.4 g/day.

Therapeutic uses

Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.

Adverse effects/Side effects

Dizziness and headache. Rash and hives. Nausea and vomiting. 

Interaction

NA

Contraindications

Hypersensitivity.

Storage

Store at 20-25°C.

Information

Molecular weight

198.2158

Molecular formula

C10H14O4

CAS number

93-14-1

Precautions

Caution should be exercised in patients with asthma, smoking, cough accompanied by excessive secretions, chronic bronchitis or emphysema, with history of persistent cough ,occurs cough with a fever, rash or persistent headache, pregnancy, lactation, porphyria.