Abacavir

Abacavir

Abacavir, 136470-78-5, Ziagen, Epzicom, Abacavir sulfate

Ziagen, Abamune, Viral, Abcavir, Abec

[(1S, 4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol

• Absorption: Orally, Bioavailabilty-83%
• Distribution: Crosses blood brain barrier, bound to plasma protein 50%
• Metabolism: Hepatic
• Elimination: Excreted through urine

Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, it is the analogue of dGTP (deoxyguanosine-5'-triphosphate). Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.

• Ziagen tablets-300 mg oral
• Ziagen solution 20mg/mL

• Occupational exposure
• HIV treatment
• Non occupational exposure

Fever, cough, anorexia, diarrhea, nausea, vomiting, headache, pancreatitis, fatigue.

• The serum concentration of Abacavir can be decreased when it is combined with the following drugs.

• 1,10-Phenanthroline
• 3,4-Dichloroisocoumarin
• 4-(2-Aminoethyl)benzenesufonyl fluoride
•  Alogliptin.
• Amprenavir

During pregnancy and lactation, in patients with renal impairment, hypersensitivity, hepatic impairment.

Store at 20-25°C.

Molecular weight

286.33

Molecular formula

C14H18N6O

CAS number

136470-78-5

Precautions

• Take without regard to meals
• Avoid alcohol because the abacavir partially metabolized through alcohol dehydrogenase enzyme system