Imipramine

Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant. It is mainly used in the treatment of major depression and enuresis.

Imipramine

Imipramine hydrochloride; Imipramine Hcl; Tofranil; Chimoreptin

Antidep, Antipres, Anxitab, Depik, Depik Forte, Depik Plus,, Depranil, Depresom-ID, Depsodep, Depsol, Depsonil, Depsonil-Plus, Depsonil-PM, Diamin, Diamin Plus, Elamin, Eldep, Imirise, Impramine, Imprine, Microdep, Ultra Dep

(3-{2-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)dimethylamine

Oral absorption.

It is a tricyclic antidepressant; this will inhibits the reuptake of serotonin that it blocks the reuptake of noradrenaline and neurotransmitters serotonin almost equally. The onset of action may be longer, up to 8 weeks, in some individuals. It is also effective in migraine prophylaxis, but not in abortion of acute migraine attack.

• Adult: PO- Initial dose: 100 mg per day given in 3 to 4 divided doses. 
• Pediatric Dose for Primary Nocturnal Enuresis: Initial dose: 25 mg per day orally 1 hour before bedtime.

• May also be used to manage panic disorders, with or without agoraphobia, as a second line agent in ADHD, management of eating disorders, for short-term management of acute depressive episodes in bipolar disorder and schizophrenia, and for symptomatic treatment of post therapeutic neuralgia.
• For the relief of symptoms of depression.

Sinus tachycardia, AV/bundle-branch block, postural hypotension, dry mouth, wt loss/gain, constipation, urinary hesitancy/retention, impotence; blurring of vision, exacerbation of glaucoma, liver dysfunction, tremors.

• Reduces hypotensive effects of bethanidine, guanethidine, bretylium, debrisoquine, methyldopa and clonidine.
•  Severe hypertension with noradrenaline, methylphenidate and adrenaline.
• Possible serotonin syndrome with MAOIs, separate admin by 3 weeks.
• Increased plasma levels and effects with quinidine, cimetidine, SSRIs, propafenone, flecainide.
•  Reduced plasma levels with barbiturates, phenytoin.
• May increase effects of anticholinergic drugs.
• Severe orthostatic hypotension with altretamine.
• Drowsiness and impaired performance may cause with alcohol.

Post MI, heart block/arrhythmias; mania; porphyria; severe hepatic impairment.

Store it at room temperature  

Molecular weight

280.4073

Molecular formula

C19H24N2

CAS number

50-49-7

Precautions

Children, cardiac disease; elderly, Epilepsy; pregnancy and lactation; DM; angle-closure glaucoma; prostatic hyperplasia; phaeochromocytoma. Monitor for increased suicidality during early treatment. Withdraw gradually.