Nalorphine

It is a narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors.

Nalorphine

Nalorphine; Allorphine; Nalorphinium; Anthorphine; Antorfin

NA

(4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol

NA

NA

Consider intravenous administration of 5-10 mg of Nalorphine as hydrochloride or hydrobromide salts, every 10-15 minutes or as needed. The maximum dose should not exceed 40 mg/day.

Reversal of opioid-induced respiratory depression (intravenously and intramuscularly).

Nalorphine can cause miosis, lethargy, acute respiratory depression, drowsiness, dysphoria and nausea.

• Nalorphine may interact with other non-opioid depressants and cardiotoxic drugs.
• Do not consume alcohol. It can cause serious adverse events.

NA

Store at 25 °C

Molecular weight

311.375 Da

Molecular formula

C19H21NO3

CAS number

62-67-9

Precautions

• Opioid-dependent patients may experience serious and acute withdrawal syndrome. May cause respiratory depression due to administration of other non-opioid depressants or alcohol.
• Patients physically dependent on opioids or who have received large doses of opioids (acute withdrawal syndrome may be precipitated).
• Pregnancy and lactation.
• Cardiac disease or patients receiving cardiotoxic medications.