An oral coagulant drug used in rat poisoning,a symmetrical isocoumarin can be considered as the "parent" of the widely used anticoagulant drug, warfarin. More
An oral coagulant drug used in rat poisoning,a symmetrical isocoumarin can be considered as the "parent" of the widely used anticoagulant drug, warfarin.
Acenocoumarol
Acenocoumarin, Nicoumalone, Nitrovarfarian, Sintrom, Nitrowarfarin
Sintrom and Sinthrome, Acitrom (0.5mg, 1mg, 2mg3 mg, 4 mg), Nistrom, Nistrom (2 mg, 4mg) Acenomac (2mg, 3mg, 4mg).
4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one
Acenocoumarol inhibits the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of certain glutamic acid residues near the N-terminals of clotting factors II, VII, IX and X, the vitamin K-dependent clotting factors. Glutamic acid carboxylation is important for the interaction between calcium and these clotting factors. Without this interaction, clotting cannot occur. Both the extrinsic (via factors VII, X and II) and intrinsic (via factors IX, X and II) are affected by acenocoumarol.
Thromboembolic disorders Adult: 4-12 mg on the 1st day and 4-8 mg on the 2nd day. Maintenance: 1-8 mg daily given in a single dose at the same time everyday by oral route of administration.
Antithrombotic/Anticoagulant, Rodenticide
Tachycardia, hypotension, gastrointestinal bleeding, and peripheral circulatory disorders due to loss of blood, nausea, vomiting, diarrhea and abdominal pains.
Lactation, Active haemorrage or risk of serious haemorrage; severe hypertension; pregnancy.
Store in a room temperature.
353.3255
C19H15NO6
152-72-7
Avoid alcohol. Bleeding disorder, peptic ulcers, severe wounds, cerebrovascular disorders, bacterial endocarditis, renal or hepatic impairment, lactation.
