Alprazolam

Alprazolam, available under the trade name Xanax, is a potent, short-acting anxiolytic of the benzodiazepine class.

Alprazolam

Alprazolam, Xanax, Tafil, Trankimazin, Cassadan

Abizox-P, Abizox-SR, Agcalm-P, Alep-SR, Alprax Forte, Alprax-SR, Alprazolam, Alprine Plus, Alprine-H, Alprocontin, Alrif-S, Alrif-XR, Alrif

12-chloro-3-methyl-9-phenyl-2,4,5,8 tetraazatricyclo[8.4.0.0²,?]tetradeca-1(10),3,5,8,11,13-hexaene

• Absorption: GI(Oral)
• Distribution: 80% protein binding
• Metabolism: Hepatic
• Excretion: Urine

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects muscle relaxation, motor coordination, anticonvulsant activity, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

• 0.25-0.5 mg/day, increased to 3-4 mg daily if necessary for the management of anxiety.
• 10 mg daily for panic attacks

• Anxiety caused by depression.

• Anxiety disorders and panic disorders 

Psychological and physical dependence, sedation, withdrawal syndrome, drowsiness, vertigo, visual disturbances, headache, GI disturbances, fatigue, jaundice, muscle weakness, dizziness, ataxia, confusion and depression.

• Alprazolam enhances activity of imipramine & despramine.
• Cimetidine & fluxetine reduce the clearance of alprazolam.

Contraindicated in patients with hypersensitivity, Increase ocular pressure and who are taking ketoconazole.

Store below 25°C.

Molecular weight

308.765

Molecular formula

C17H13ClN4

CAS number

28981-97-7

Precautions

Patients of respiratory disorders, kidney or liver impairments should be take caution.