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Amantadine,

Amantadine is an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). More

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Description

Amantadine is an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A).

Generic Name

Amantadine,

Chemical names

1-Aminoadamantane, Amantadine, 1-Adamantanamine, Adamantan-1-amine

Brand names

Amantrel, Flublast, Flublast Tab, Parkitidin

IUPAC name

adamantan-1-amine

Pharmacokinetics

  • Absorption: Oral
  • Distribution: Plasma protein bound 67%
  • Excretion: Urine

Actions

Amantadine is an antiviral drug which also acts as an antiparkinson agent, for which it is usually combined with L-DOPA when Levo DOPA responses decline. It is a derivate of adamantane, like a similar drug rimantadine. It has been shown to cause an increase in dopamine release in the animal brain, and does not possess anticholinergic activity.

Dosage/Dosage form

The recommended daily dosage of Amantadine is 200 mg in either single or divided doses.

Therapeutic uses

Anti-parkinsonism, Viral infections such as influenza A virus, certain types of flu.

Adverse effects/Side effects

Depression, headache, confusion, fatigue, dry nose, eye inflammation, constipation, diarrhea.

Interaction

Avoid using FluMist (nasal flu vaccine) while are taking Amantadine. Do not consume alcoholic beverages, coffee and even caffeinated drinks, these beverages could impair the Amantadine metabolism.

Contraindications

Pregnancy, lactation and in elder people

Storage

Store at 20-25°C.

Information

Molecular weight

151.24

Molecular formula

C10H17N

CAS number

768-94-5

Precautions

Do not take Amantadine if you are diagnosed with congestive heart failure, hypotension, renal disorders, eczema, glaucoma, hepatic disorders, epileptic disorders, history of mental illness with or without drug/alcohol addiction.