Amikacin

It is an antibiotic used for a number of bacterial infections. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections.

Amikacin

Amikacin, Amicacin, Amikacine, Amikacina

Acil, Acmacin, Alfakim, Amexel, Amibiotic, Amicin, Amidol, Amikacin, Amikamac, Amikater, Amikavel, Amilab, Amimac, Amimax, Aminocin, Amiron

(2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-{[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-{[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanami

• Absorption: Rapidly absorbed through intramuscular route, poorly absorbed through topical and oral route of administration.
• Distribution: 0-11% protein binding
• Excretion: Urine

Amikacin is an aminoglycoside antibiotic. Aminoglycosides are useful primarily in infections involving Gram-negative bacteria (Acinetobacter, Pseudomonas and Enterobacter) and aerobic bacteria work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA. These are mostly ineffective against anaerobic bacteria, fungi and viruses.

15 mg/kg/day intramuscular injection

Bacterial infections

Acute muscular paralysis and apnea, hearing loss and loss of balance, induce auditory, vestibular, and renal toxicity and neuromuscular blockade.

Amphotericin B may lead to increased nephrotoxicity and reduced clearance of amikacin when used together. Enhanced neuromuscular blockade with neuromuscular blocking drugs. Increased nephrotoxic or ototoxic effects with other nephrotoxic or ototoxic drugs. 

Contraindicated during Pregnancy and lactation, peforated ear drums, myasthenia gravis, hypersensitivity.

Store at 15-30°C.

Molecular weight

585.6025

Molecular formula

C22H43N5O13

CAS number

37517-28-5

Precautions

Discontinue if signs of ototoxicity, neurotoxicity or hypersensitivity occurs.

Monitor renal function before and during treatment.