Aminophylline

Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate.

Aminophylline

Aminophylline, Phyllocontin, Aminophyllin, Somophyllin, Truphylline

Aminophylline, Biofylin, Cortasthma, Dialex, Broncofree, Minophyl, Phyllocontin

bis (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine

• Absorption: Rate of absorption delayed by food.
• Distribution: Crosses the placenta.
• Metabolism: hepatic metabolism.
• Excretion: Urine

It is the salt ethylenediamine of theophylline. Theophylline stimulates the skeletal muscles, CNS, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion.

• 225-450 mg twice daily per oral for chronic bronchospasm, increase the as per the need.
• 5 mg/kg IV for severe bronchospasm

Asthma, emphysema and bronchitis.

Nausea, vomiting, diarrhea, abdominal pain, insomnia, headache, anxiety, dizziness, restlessness, and palpitations. Tremor,
Potentially Fatal: Convulsions, hypotension, cardiac arrhythmias and quick death after too rapid IV injection.

• β-blockers inhibit metabolism.
• Increased risk of cardiac arrhythmias with sympathomimetics and halothane.
• Increased risk of convulsion with quinolones, ketamine.
• Tachycardia with pancuronium. 

Hypersensitivity, Caution when used during pregnancy, lactation and in infants.

Store below 25°C, keep these medications in air closed container.

Molecular weight

420.4264

Molecular formula

C16H24N10O4

CAS number

317-34-0

Precautions

Neonates, elderly, lactation, cardiac/hepatic diseases, pregnancy, hyperthyroidism, peptic ulceration, hypertension, heart failure, epilepsy, chronic alcoholism, acute febrile illness.