Amlodipine

Amlodipine is an oral drug that’s used to treat high blood pressure, coronary artery disease, and angina.

Amlodipine

Amlodipine, Norvasc, Amlocard, Amlodis, Coroval

Acedip, Aglodepin-AT, Acepril-A, Acord, Alis, Alis plus, Adipin, Alis-AT, Adipin Plus, ADP, Adpine-AT, Aglodepin, Alodip-AT, Alip-AM, Alis-R, Amace-BP, Alodip, Alsartan-AM, AM-5, Amace, Amaday, Amanat, Amark-5, Amat, Amcar

NA

• Absorption: Gastrointestinal tract
• Distribution: 97.5% protein binding
• Metabolism: Hepatic
• Excretion: Urine

Amlodipine is a long-acting CCB that may be used to treat chronic stable angina (exertion-related angina) and mild to moderate essential hypertension. It also  inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracellular calcium influx through calcium channels.

PO 5 to 10 mg every day.

In Prinzmetal's angina, hypertension and in Stable angina.

Headache, peripheral oedema, fatigue, somnolence, nausea, abdominal pain, flushing, dyspepsia, palpitations, and dizziness. Rarely pruritus, rash, dyspnoea, asthenia, muscle cramps, hypotension, bradycardia

Grape fruit can significantly increase serum levels of Amlodipine and may cause toxicity.

Hypersensitivity to dihydropyridnes with Amlodipine.

Store in tightly closed container in cool location at 59° to 86°F.

Molecular weight

408.876

Molecular formula

C20H25ClN2O5

CAS number

88150-42-9

Precautions

• Caution when used in patients with idiopathic hypertrophic subaortic stenosis. Elderly, children, pregnancy & lactation.
• Avoid excess dosage
• Caution should be exercised when administering to patients with severe aortic stenosis and severe hepatic impairment.