Amoxapine

Amoxapine is a tetracyclic antidepressant of the dibenzoxazepine family, though it is often classified as a secondary amine tricyclic antidepressant. It is the N-demethylated metabolite of loxapine.

Amoxapine

Amoxapine, Demolox, Asendin, Amoxan

Amolife, Demolox, Oxamine, Oxcap

13-chloro-10-(piperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0³,?]pentadeca-1(11),3,5,7,9,12,14-heptaene

• Absorption: Oral(Readily absorbed from the GI tract )
• Distribution: Enters breast milk, extensive protein binding
• Metabolism: Hepatic, Undergoes hydroxylation
• Excretion: Urine

Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. Amoxapine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).

50-100 mg, two or three times a day per oral

Prescribed for depression

Postural hypotension, conduction disturbances, tachycardia, dry mouth, blurring of vision, constipation, urinary retention, fatigue, dizziness, weakness, tremors, headache, confusion and delirium in elderly, weight gain, tardive dyskinesia, neuroleptic malignant syndrome, sexual disturbances.

• Reduced serum levels with barbiturates.
• Potentiates sedative effect of alcohol.
• Potentiates hypertensive effects of sympathomimetics.
• Reduces effect of antihypertensives. 
• Antiparkinson agents, antipsychotic drugs increase risk of anticholinergic effects. 
• Marked hyperpyrexia, convulsions and coma with MAOIs.

Hypersensitivity, recent MI, concurrent treatment with MAOIs, mania, heart block or other cardiac arrhythmias, severe liver disease.

Keep this medication in a tightly closed container, out of reach of children.

Molecular weight

313.781

Molecular formula

C17H16ClN3O

CAS number

14028-44-5

Precautions

Caution should be exercised in patient with heart problems, blood disorders, and overactive thyroid. Overdose may result in coma.