img

Amphetamine

Amphetamine is a potent central nervous system stimulant that is used in the treatment of attention deficit hyperactivity disorder, narcolepsy, and obesity. More

Sharing is caring, show love and share the thread with your friends.

Description

Amphetamine is a potent central nervous system stimulant that is used in the treatment of attention deficit hyperactivity disorder, narcolepsy, and obesity.

Generic Name

Amphetamine

Chemical names

Dextroamphetamine; D-Amphetamine; Dexamphetamine; Dexamfetamine; (S)-Amphetamine; (+)-Amphetamine

Brand names

Adderall (International trade name)

IUPAC name

1-phenylpropan-2-amine

Pharmacokinetics

  • Distribution: 15-40% protein binding
  • Excretion: urine

Actions

Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the nigrostriatal dopamine systems and the mesocorticolimbic system. It is also acts as an agonist on central 5-HT receptors directly and may inhibit monoamine oxidase (MAO).

Dosage/Dosage form

The recommended dose is 10 mg/day; the dose will be increase after a week up to 20 mg/day if needed.

Therapeutic uses

For treatment of Attention Deficit Disorder with Hyperactivity (ADDH), narcolepsy

Adverse effects/Side effects

Abdominal pain, loss of sleep and appetite, weight loss, depression, headache, nausea and nervousness.

Interaction

Amphetamine can interact with insulin and other anti-diabetic drugs, lithium, haloperidol, phenothiazine, guanethidine, tricyclic anti-depressants and doxazosin.

Contraindications

Amphetamine is contraindicated in patients with elevated ocular and blood pressure, hyperthyroidism, heart diseases, history of drug,  arteriosclerosis,  alcohol abuse, anxiety disorders, diabetes mellitus, Tourette’s syndrome, seizure disorders.

Storage

Store at 20-25°C.

Information

Molecular weight

135.2062

Molecular formula

C9H13N

CAS number

300-62-9

Precautions

Caution should be taken in patients of high blood pressure, kidney or liver problems, heart diseases, mood or mental problems, during pregnancy and breast feeding.