Amrinone

Amrinone or inamrinone, trade name Inocor, is a pyridine phosphodiesterase 3 inhibitor. It is a drug that may improve the prognosis in patients with congestive heart failure.

Amrinone

Amrinone, Inamrinone, Wincoram, Inocor

Amicor, Amrisol, Cardiotone

3-amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one

• Distribution: 10-49% protein binding
• Metabolism: Hepatic( Partially metabolized through liver)
• Excretion: Urine (excreted unchanged-40%)

Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.

• Loading dose: 750 mcg/kg by slow inj over 2-3 min
• Max cumulative dose: 10 mg/kg in 24 hr.
• Maintenance dose: 5-10 mcg/kg/min by infusion.

Used in the treatment of congestive heart failure.

GI disturbances, nausea, thrombocytopaenia, vomiting, hypotension, hypersensitivity, chest pain, myositis, nail discoloration, vasculitis, Inj site pain. Potentially Fatal: Cardiac arrhythmia, hepatotoxicity.

• Concurrent usage with disopyramide may lead to severe hypotension.

• Chemical interaction with precipitation occurs with amrinone and dextrose or furosemide. Thus drug mixing should be avoided.

Hypersensitivity, Pregnancy and lactation

Store at 15-30°C (IV)

Molecular weight

187.198

Molecular formula

C10H9N3O

CAS number

60719-84-8

Precautions

• Furosemide should not be administered into an IV line delivering Amrinone.
• Amrinone must be diluted in a 1/2 normal saline or normal saline; dextrose solutions should not be used for dilution. 
• Obstructive pulmonary or aortic disease, hypertrophic cardiomyopathy; platelet counts and liver function should be monitored; BP and heart rate monitored during drug administration; fluid and electrolyte balance should be maintained; Pregnancy and lactation. Protect amp from light.