Anastrozole

Anastrozole, sold under the trade name Arimidex among others, is a medication used in addition to other treatments for breast cancer.

Anastrozole

Anastrozole, Anastrazole, Arimidex, Anastrozol

Altraz, Altrol, Anabrez, Anaday, Anazol, Anzucia, Arimidex, Armilon, Armotraz, Azoleres, Redest, Stazonex

2-[3-(1-cyano-1-methylethyl)-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

• Absorption: Oral
• Distribution: 40% protein binding
• Metabolism: Hepatic
• Excretion: Via urine

It is selectively inhibits aromatase, aromatase inhibition leads to a decrease in tumor concentration of estrogen and serum, leading to a delayed progression of tumor growth or decreased tumor mass in some women.

1 mg daily oral

• For adjuvant treatment of hormone receptor positive breast cancer, as well as hormonal treatment of advanced breast cancer in post-menopausal women. 
• McCune-Albright syndrome
• Has also been used to treat pubertal gynecomastia

Hot flushes, vaginal dryness, vaginal bleeding, rash, hair thinning, anorexia, myalgia, nausea, vomiting, diarrhoea, headache, arthralgia, bone fractures, oedema, asthenia, fever, flu-like syndrome, weight gain, leucopenia, dizziness, drowsiness, abnormal liver enzyme values, thrombophloebitis, anaphylaxis.

• Estrogens may diminish the actions of anastrozole.
• Coadministration of Tamoxifen, Estrogens is not recommended.

Hypersensitivity, Pregnancy. Premenopausal women and lactation

Store at 20-25°C oral dosage forms

Molecular weight

293.3663

Molecular formula

C17H19N5

CAS number

120511-73-1

Precautions

• Bone mass density test should be conducted at the start of the therapy and at regular intervals thereafter.
• Moderate or severe hepatic impairment
• Laboratory test for menopause if status is doubtful.