Apomorphine

Apomorphine is a type of aporphine having activity as a non-selective dopamine agonist which activates both D?-like and, to an order of magnitude lesser extent, D?-like receptors.

Apomorphine

Apomorphine, Apokyn, Apomorphin, Uprima, L-Apomorphine

Zyprima

(9R)-10-methyl-10-azatetracyclo[7.7.1.0²,?.0¹³,¹?]heptadeca-1(16),2(7),3,5,13(17),14-hexaene-3,4-diol

• Absorption: Well absorbed-100% bioavailability after subcutaneous administration
• Distribution: ~50%-albumin
• Metabolism: Hepatic
• Excretion: Urine

Apomorphine is a type of dopaminergic agonist, in higher doses it is a highly effective emetic. Drugs containing this substance are sometimes used in the treatment of erectile dysfunction or Parkinson's disease. 

Initial dose is 2 mg (0.2ml) 3 times a day.

In Refractory motor fluctuations in Parkinson's disease and in erectile dysfunction. 

Nausea and vomiting; transient sedation; dyskinesia; dizziness; yawning; drowsiness; postural hypotension; CNS stimulation; pharyngitis; increased salivation and perspiration; neuropsychiatric disturbances; eosinophilia; rhinitis; cough; flushing; taste disturbance; vaso vagal syndrome. 

Antipsychotics, antihypertensives, CNS dopamine inhibitors, organic nitrates, entacapone and memantine.

• Patients who have an 'on' response to levodopa marked by severe dyskinesia; hypotonia; or psychiatric effects.
• Respiratory or CNS depression, dementia, neuropsychiatric problems, recent MI, severe heart failure, severe unstable angina, pregnancy, hypotension, breast-feeding. 
• Combination treatment with other drugs for erectile dysfunction.
• Hypersensitivity to opioids

Store at 25°C.

Molecular weight

267.3224

Molecular formula

C17H17NO2

CAS number

58-00-4

Precautions

• Before starting apomorphine to treat parkinsonism disease, domperidone should be given for at least 2 days before the treatment.
• Patients with anatomical penile deformity. 
• Debilitated or elderly patients