Aspirin

Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation.

Aspirin

Aspirin; 2-Acetoxybenzoic acid, Acetylsalicylic acid, Ecotrin

A.S.A, Atoplus, Alpyrin, Anacin, Antiban-ASP, Apidin, Arreno, Caplor-AS, ASA, Ascad, Asicom, Asicom PLUS, Asogrel-A, ASP-Atorva, Aspent, Aspin, Aspisol, Aspitrate, Astic, Atchol ASP, Aztor-ASP 150, Atosa, C-Grel Plus, Azto

2-(acetyloxy)benzoic acid

• Absorption: Oral
• Distribution: 80-90% protein binding
• Metabolism: Hepatic
• Excretion: Urine

Acetylsalicylic acid is an analgesic, antipyretic, antirheumatic, and anti-inflammatory agent, acts by inhibiting the synthesis and release of prostaglandins. 

• 75-325 mg once daily for the prophylaxis of myocardial infarction
• 325 mg 2 hr before procedure followed by 160-325 mg/day thereafter for stent implantation. 
•  2.4-3.6 g/day in divided doses for Pain and inflammation associated with musculoskeletal and joint disorders.
• 325-650 mg repeated every 4-6 hr according to response for mild to moderate fever and pain.

• Analgesic
• Prophylaxis of myocardial infarction
• Anti inflammatory 

Gastric erosion, ulceration and bleeding; severe, occasionally fatal exacerbation of airway obstruction in asthma, prolonged bleeding time, rhinitis, urticaria and epigastric discomfort; angioedema, salicylism, tinnitus; bronchospasm.

• Vitamin-rich foods increase urinary excretion
• Aspirin increases phenytoin levels.
• Alcohol, corticosteroids, analgin, phenylbutazone and oxyphenbutazone may increase risk of GI ulceration.
• May potentiate effects of anticoagulants, methotrexate and oral hypoglycaemics.
• May antagonize actions of uricosurics and spironolactone.

Hypersensitivity, active peptic ulceration; pregnancy (3rd trimester), gout, severe renal or hepatic impairment, lactation.

Store it at room temperature

Molecular weight

180.1574

Molecular formula

C9H8O4

CAS number

50-78-2

Precautions

History of peptic ulcer or those prone to dyspepsia and those with gastric mucosal lesion, asthma or allergic disorders, uncontrolled hypertension, dehydrated patients, impaired renal or hepatic function, elderly.