Atenolol

Atenolol is a selective ?? receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases.

Atenolol

Atenolol; Tenormine; Tenormin; Blokium

UTL (25 mg), Atenova-H (25mg/12.5mg), Coronol (25 mg), Tenocab (50+5 mg), Atcom (25 mg), Carden (25mg), Aten-AM (5mg/50mg), Teny (50 mg), Atemos –AT, Amlodac-AT (5mg/50mg), Anol (50mg), Repalol H, Nusar - ATN (50mg/50m

2-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide

• Absorption: 50% of an oral dose is absorbed from the gastrointestinal tract
• Distribution: 6-16% protein binding
• Metabolism: Hepatic
• Excretion: Feces

Atenolol, a competitive beta (1)-selective adrenergic antagonist,with the lowest lipid solubility of this class of drugs. Atenolol is used alone in the management of hypertension and with chlorthalidone to treat edema.

• 25-100 mg daily as a single dose for hypertension
• 50-100 mg daily given as single or divided doses for angina pectoris and for Migraine prophylaxis

In angina pectoris, as prophylaxis of migraine and in hypertension

Bronchospasm; cold extremities, heart failure, fatigue, dizziness, insomnia, lethargy, confusion, headache, depression, nightmares, nausea, diarrhoea, constipation, impotence and paraesthesia.

• May increase effects of drugs which slow AV conduction (digoxin, verapamil, diltiazem).
• Decreased effect with aluminum and calcium salts, barbiturates, cholestyramine, NSAIDs, ampicillin, rifampicin.

• Hypersensitivity, sinus node dysfunction and Sinus bradycardia

Store at 20-25°C.

Molecular weight

266.3361

Molecular formula

C14H22N2O3

CAS number

29122-68-7

Precautions

• Unabsorbed drug may be removed by induced emesis, gastric lavage or admin of activated charcoal.
• Lactation.
• Compensated heart failure.