Atovaquone

Atovaquone is a chemical compound that belongs to the class of naphthoquinones. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.

Atovaquone

Mepron; Wellvone; Acuvel; 566C80

Mepron

2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione

Atovaquone is a highly lipophilic drug, in sensitive parasites atovaquone acts selectively by affecting mitochondrial electron transport and parallel processes such as ATP and pyrimidine biosynthesis. 

The recommended oral dose is 1500 mg/10ml once daily administered with meals.

Pneumocystis carinii Pneumonia, Malaria

Flu like syndrome, fever, headache, nausea, vomiting, abdominal pain and difficulty in breath.

Drinking alcoholic beverages will impair the Atovaquone metabolism, and increases the level of drug in the blood that may lead to serious side effects.

Pregnancy and hypersensitivity

Store at 20-25°C.

Molecular weight

366.837

Molecular formula

C22H19ClO3

CAS number

95233-18-4

Precautions

• Atovaquone may interact with rifabutin, rifampicin, carbamazepine and clozapine.
• Do not use Atovaquone in patients with hepatic and/or intestinal disorders.