Atracurium besilate

Atracurium besilate is a medication used in addition to other medications to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Atracurium besilate

Atracurium besylate; Tracrium; Atracurium besilate; Atracurii besilas

Acris, Acubax, Arium, Artacil, Artacil-50, Atcurium, Atcuron, Atracade, Atrakt, Atrapure, Atrelax, Kabitran, Tracrium, Troycurium

1-[(3,4-dimethoxyphenyl)methyl]-2-[3-({5-[(3-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propanoyl)oxy]pentyl}oxy)-3-oxopropyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro

• Distribution: 80% protein binding
• Excretion: Bile and urine

Atracurium antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. 

Initially, 300-600 mcg/kg as injection. Subsequently, 100-200 mcg/kg when necessary or every 15-25 minutes for maintenance in prolonged procedures.

Used as an adjunct to general anesthesia

Cutaneous reactions; bradycardia, transient hypotension in patients with CVS disorders; dyspnoea, bronchospasm; rash and urticaria.

• Ketamine may potentiate the effects of atracurium.
• Mixed block with suxamethonium which is difficult to reverse with anticholinergic drugs.
• Concurrent use with tamoxifen or danazol may prolong effects of atracurium.
• Malignant hyperthermia with halogenated anaesthetics and succinylcholine.
• Neuromuscular blockade potentiated by parenteral Mg salts, anaesthetics, aminoglycosides and polypeptide antibiotics, and botulinum a toxin.
• MAOIs.

Hypersensitivity

Refrigerate at 2-8°C. Do not freeze. 

Molecular weight

1243.49

Molecular formula

C65H82N2O18S2

CAS number

64228-81-5

Precautions

• Dosage for obese patients should be based on ideal body-weight to prevent overdosing.
• Neonates