Azatadine

Azatadine is a first-generation antihistamine and anticholinergic that was launched Schering-Plough in 1973. It was patented in 1967. It has been succeeded by other antihistamines and marketing approvals have been widely withdrawn.

Azatadine

Azatadinum; Optimine; Azatadina; Azatadine maleate

Zadine, Glutazine

2-(1-methylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.0³,?]pentadeca-1(15),3(8),4,6,11,13-hexaene

• Absorption: GI tract(Oral)
• Metabolism: Hepatic
• Excretion: Urine

This drug reduces the intensity of allergic reactions and tissue injury response involving histamine release.

1 mg bid increased to 2 mg bid if needed.

Used to treat sneezing; watery eyes; runny nose; itching, hives; rashes; itching; and other symptoms of allergies and the common cold.

Drowsiness, headache, dizziness, fatigue, nervousness; thick bronchial secretions; anticholinergic effects, arthralgia; increased appetite, pharyngitis; wt gain, nausea, diarrhoea, dry mouth; abdominal pain, impaired alertness.

• MAOIs enhance anticholinergic side effect of azatadine.
• Alcohol may enhance sedative effects
• CNS depression potentiates by procarbazine, TCAs and alcohol.
• Enhance depressant action of anxiolytic and sedating drugs.

• Neonates
• Lactation.
• Patients receiving MAOI therapy

Store at 2-30°C.

Molecular weight

290.4021

Molecular formula

C20H22N2

CAS number

3964-81-6

Precautions

• May impair ability to drive or operate machinery
• Angle-closure glaucoma, increased intraocular pressure, stenosing peptic ulcer, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment.
• Pregnancy.