Azithromycin

Azithromycin is an antibiotic useful for the treatment of a number of bacterial infections. This includes middle ear infections, strep throat, pneumonia, traveler's diarrhea, and certain other intestinal infections.

Azithromycin

Azithromycin; Zmax; Zithromax; Azithromycine; Azithromycinum

Acin, Azithrot, Azza, Miomycin, Nodycin, Dezithro, Meraz, Aziagio FC, Azibiotic, AZR, AZM, Ziz, Azicure, Xith, Azilup, Azicos, Azigreat

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,6,8,10,12,14-heptam

• Absorption: Oral
• Distribution: Extensively through WBC, tissues and through CSF
• Metabolism: Hepatic
• Excretion: Biliary excretion via bile and urine

Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells.

• Typhoid fever: 500 mg once daily for 7 days, IV.
• Uncomplicated gonorrhea: 2g as a single dose
• Respiratory tract infection and for skin and soft tissue infections: 500 mg once daily for three days. 

Laryngitis, middle ear infections, non-gonococcal urethritis and cervicitis, tonsillitis, bronchitis, throat infections, Typhoid, pneumonia and sinusitis. 

Mild to moderate nausea, abdominal pain, vomiting, flatulence, dyspepsia, cramping, diarrhoea, cholestatic jaundice, angioedema, headache, dizziness, somnolence, vertigo and transient elevations of liver enzyme values.

• Increased serum concentrations of digoxin and ciclosporin.
• Antacids containing aluminium and magnesium salts reduce rate of absorption.
• Food may alter absorption
• Increased risk of ergot toxicity.

Hypersensitivity

Store below 30°C.

Molecular weight

748.9845

Molecular formula

C38H72N2O12

CAS number

83905-01-5

Precautions

Monitor patient's response to therapy.