Aztreonam

Aztreonam is a monobactam antibiotic used primarily to treat infections caused by gram-negative bacteria. It is a synthetic drug based on a simpler monobactam isolated from Chromobacterium violaceum.

Aztreonam

Aztreonam; Primbactam; Azactam; NSC646279

Azactam, Azenam, Azom INJ, Azotum, Azpic, Aztreo, Namy, Qualitreo, Rez, Treonam, Trezam U-Azom, Zitronam, Zonam

(2S,3S)-3-[(2Z)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-methyl-4-oxoazetidine-1-sulfonate

Aztreonam inhibitits bacterial cell wall synthesis by binding to PBP3. 

• 1 g as a single dose for gonorrhoea.
• 1-8g/day in divided doses for the treatment of gram negative bacterial infections as IM/IV
• 0.5-1g 8to12 hours for urinary tract infections
• 75 mg 3days daily as  inhalation

Urinary tract infections and lower respiratory tract infections.

Thrombocytopenia, diarrhoea, neutropenia; pseudomembranous colitis overgrowth of susceptible organisms, nausea, vomiting, altered taste; jaundice, hepatitis, Pain and swelling,  high liver enzymes; partial thromboplastin time; long prothrombin time, rash, urticaria, eosinophilia.

Concurrent use with oral anticoagulants may increase prothrombin time

Hypersensitivity; lactation

Once reconstituted, it should be used within 48 hr if stored at 15-30°C or 7 days if stored at 2-8°C.

Molecular weight

435.433

Molecular formula

C13H17N5O8S2

CAS number

78110-38-0

Precautions

Hypersensitivity to other β-lactams; renal and hepatic impairment; Reduced dose required, pregnancy.