Bacampicillin

Bacampicillin is a penicillin antibiotic. It is a prodrug of ampicillin with improved oral bioavailability. It is sold under the brand names Spectrobid and Penglobe

Bacampicillin

Bacampicillin; Bacampicillinum; Bacampicilline; Bacampicilina; Penglobe;

Penglobe, Spectrobid

1-[(ethoxycarbonyl)oxy]ethyl (2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

• Absorption: Oral(GI tract)
• Excretion: Urine

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive.

400-800 mg 2-3 times/day

Prescribed for uncomplicated gonorrhea and for susceptible infections

CNS toxicity, uticaria; joint pains; rashes, angioedema; serum sickness-like reactions; haemolytic anaemia, neutropenia; convulsions; diarrhoea; thrombocytopenia; antibiotic-associated colitis. Nausea, fever, vomiting, interstitial nephritis, pseudomembranous colitis.

• Bacteriostatic drugs e.g. tetracyclines, chloramphenicol, and other antibacterials.
• Probenecid prolongs T1/2 of bacampicillin. 
• Anticoagulants.

HIV infection, Infectious mononucleosis, lymphatic leukemia, hypersensitivity to penicillins

Store it at room temperature

Molecular weight

465.52

Molecular formula

C21H27N3O7S

CAS number

50972-17-3

Precautions

• Avoid contact, skin sensitisation may occur.
• Discontinue in case of skin rash.
• Monitor serum potassium concentration, renal and haematological status. 
• Avoid intrathecal route.