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Bacitracin-used to prevent minor skin infections caused by small cuts, scrapes, or burns.

Bacitracin is a mixture of related cyclic peptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, More

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Description

Bacitracin is a mixture of related cyclic peptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy,

Generic Name

Bacitracin-used to prevent minor skin infections caused by small cuts, scrapes, or burns.

Chemical names

Baciguent; UNII-DDA3RRX0P7; Bacitracin A; Baciim; Mycitracin DDA3RRX0P7

Brand names

Derbec-N, Nebaspor, Intasporin, Nebaspor POWD, Nebasulf Skin Oint, Nebasulf, Neosporin POWD, Neosporin-H OINT, Neosporin Skin, Neotop

IUPAC name

Pharmacokinetics

Actions

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin exerts pronounced antibacterial action in vitro against a few gram-negative and a variety of gram-positive organisms. 

Dosage/Dosage form

Topical/Cutaneous

  • 10,000-25,000 u every 6 hr. Max: 100,000 u/day and 25,000 u/dose. 

Therapeutic uses

In Vancomycin-resistant enterococci infections and in Clostridium difficile-associated colitis and diarrhoea (effective orally), in Local infections (topical/cutaneous) and in Staphylococcal infections (intramuscular). 

Adverse effects/Side effects

Systemic admin: Nausea, vomiting, hypersensitivity reactions, severe nephrotoxicity, inj site pain.

Interaction

Increased risk of nephrotoxicity when used with other nephrotoxic drugs.

May enhance the action of neuromuscular-blocking agents.

Contraindications

Hypersensitivity

Renal impairment

Storage

Store at room temperature

Information

Molecular weight

1422.693

Molecular formula

C66H103N17O16S

CAS number

1405-87-4

Precautions

Pregnancy, lactation, Avoid prolonged use. IM use may cause renal failure. Do not admin IV (severe thrombophloebitis)