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Balsalazide-used to treat inflammatory bowel disease.

Balsalazide is an anti-inflammatory drug. It is converted in the body to mesalamine and works by reducing bowel inflammation, diarrhea, rectal bleeding, and stomach pain. More

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Description

Balsalazide is an anti-inflammatory drug. It is converted in the body to mesalamine and works by reducing bowel inflammation, diarrhea, rectal bleeding, and stomach pain.

Generic Name

Balsalazide-used to treat inflammatory bowel disease.

Chemical names

Balsalazido; Balsalazidum; Balsalazida; Colazide; Balsalazidum

Brand names

Balacol, Colorex, Cozabal, Intazide

IUPAC name

5-[(E)-2-{4-[(2-carboxyethyl)carbamoyl]phenyl}diazen-1-yl]-2-hydroxybenzoic acid

Pharmacokinetics

Actions

Dosage/Dosage form

2.25g 3times/day until remission

Therapeutic uses

Active ulcerative colitis.

Adverse effects/Side effects

Diarrhoea, nausea, abdominal pain, headache, vomiting, exacerbation of symptoms of colitis, hepatitis, hypersensitivity reactions (including rash and urticaria). Adverse effects that occur rarely include acute pancreatitis, pericarditis, lung disorders, peripheral neuropathy, myocarditis, blood disorders, renal dysfunction (, myalgia, arthralgia, skin reactions and alopecia.

Interaction

  • Meglitinide antidiabetics (eg, repaglinide), sulfonylureas (eg, glipizide), or valproic acid because the risk of their side effects may be increased by Balsalazide ACE (Angiotensin-converting enzyme) inhibitors.

Contraindications

Hypersensitivity

Storage

Store at 25 ?

Information

Molecular weight

357.3175

Molecular formula

C17H15N3O6

CAS number

80573-04-2

Precautions

Renal impairment, pregnancy, lactation; blood disorders can occur.