Barnidipine-It is an calcium channel blocker

Barnidipine or mepirodipine is a calcium channel blocker.

Barnidipine-It is an calcium channel blocker

Barnidipine; Mepirodipine; Barnidipine HCl; UNII-2VBY96ASWJ

Mepirodipine

3-(3S)-1-benzylpyrrolidin-3-yl 5-methyl (4S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

The drug exerts vasodilatation with reduced peripheral resistance, after load and blood pressure with increased heart rate, coronary blood flow, oxygen supply and cardiac output. Barnidipine is a peripheral and coronary vasodilator with no effects on cardiac conduction. 

• initial dose of 5-10 mg once daily
• maintenance dose 10-20 mg once daily

For the treatment of hypertension and chronic stable angina.

• Barnidipine may interact with erythromycin, rifampicin, aldesleukin, antihypertensive drugs, quinidine, phenytoin, rifampicin, erythromycin, carbamazepine, anti-psychotics and cimetidine.
• Do not consume grapefruit, grape wine, grape fruit juice while taking Barnidipine.

Store at room temperature

Molecular weight

491.544

Molecular formula

C27H29N3O6

CAS number

104713-75-9

Precautions

Barnidipine is contraindicated in patients with cardiogenic shock, poor cardiac reserve, heart failure, aortic stenosis, recent history of unstable angina or MI, aortic stenosis and hypotension. Do not stop Barnidipine treatment abruptly.