Benazepril-Angiotensin converting converting enzyme ACE inhibitor

Benazepril, brand name Lotensin, is an ACE inhibitor used primarily in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing the renal and retinal complications of diabetes.

Benazepril-Angiotensin converting converting enzyme ACE inhibitor

Benazepril; Benazeprilum; Benazeprilum; Cibacen

Amace-BP, Amlo-B, Benace

2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid

• Absorption: Oral
• Distribution: 97% protein binding
• Metabolism: Hepatic
• Excretion: Mainly via urine, bile

Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which, when hydrolyzed by estarases to its active Benazeprilat, it inhibit ACE (angiotensin-converting enzyme). ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to angiotensin II (the vasoconstrictor substance). Angiotensin II also stimulates aldosterone secretion by the adrenal cortex.

10 mg once daily

To treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure.

Drowsiness, headache, fatigue, dizziness, nausea, vomiting, constipation, hair loss and sweating.

• Thiazides and other diuretics may cause excessive fall in BP when used with benazepril.
• Concomitant potassium-sparing diuretics or potassium supplements can increase the risk of hyperkalaemia.
• Increased risk of lithium toxicity when used concurrently. 

Hypersensitivity. History of bilateral renal artery stenosis, angioedema; pregnancy.

Store at 20-25 deg centigrade

Molecular weight

424.4895

Molecular formula

C24H28N2O5

CAS number

86541-75-5

Precautions

Do not drive or handle machinery it may cause drowsiness, avoid excess dosage.