Bendamustine is a bifunctional mechlorethamine derivative with alkylating and antimetabolite activities. More
Bendamustine is a bifunctional mechlorethamine derivative with alkylating and antimetabolite activities.
Bendamustine-is a chemotherapy medication used in the treatment of chronic lymphocytic leukemia
Bendamustine; Bendamustina; Bendamustinum; SDX-105
Bendit, Bimode, Maxtorin, Mustin, Purplz, Rolanda
4-{5-[bis(2-chloroethyl)amino]-1-methyl-1H-1,3-benzodiazol-2-yl}butanoic acid
Bendamustine forms a covalent bond with nucleophilic moieties that result in interstand DNA crosslinks. The bifunctional covalent cross linking leads to chemical cell death.
The recommended dose is 100 mg/m2 over 30 min IV infusions on days 1&2 of 28 days cycle, up to 6 cycles.
Treatment of chronic lymphocytic leukaemia, non-Hodgkin’s lymphoma.
Fever, nausea, headache, vomiting, fatigue, drowsiness, cough, mouth ulcers, constipation and abdominal pain.
Bendamustine may interact with thiabendazole, ciprofloxacin, carbamazepine, barbiturates, fluvoxamine, cimetidine and omeprazole.
Bendamustine is contraindicated in smokers, patients with hepatic diseases, metabolic disorders, infections, immune disorders, liver diseases and renal disorders.
Store at 20-25°C.
358.263
C16H21Cl2N3O2
16506-27-7
Do not use drive vehicles or operate machineries while taking Bendamustine.
