Benidipine-calcium channel blocker for the treatment of hypertension and angina

Benidipine is an orally bioavailable dihydropyridine antagonist of L-type, N-type and T-type calcium channels.

Benidipine-calcium channel blocker for the treatment of hypertension and angina

Benidipine hydrochloride; Benidipine (hydrochloride); KW 3049; (+-)-Benidipine hydrochloride

Caritec

3-(3R)-1-benzylpiperidin-3-yl 5-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Oral dose of 2-4 mg once daily increase the dose upto 8 mg if necessary 

For the treatment of hypertension and chest pain.

Palpitation, headache, abdominal discomfort, facial flushing, sleepiness, nausea, hot flushes, chest pressure sensation, dizziness, constipation, oedema, tinnitus, redness and warm feeling in the fingers, shoulder stiffness, hypersensitive reactions, elevation of SGOT, SGPT, total bilirubin, alkaline phosphatase, creatinine and uric acid.

• Cimetidine may inhibit benidipine metabolism.
• β-blockers or diuretics may enhance BP control.
• Serum concentrations of digoxin may be increased. 

Contraindicated in pregnancy and lactation.

Store it at room temperature.

Molecular weight

505.571

Molecular formula

C28H31N3O6

CAS number

105979-17-7

Precautions

• In case of lightheadedness or dizziness, advise patients against working at elevated spots or handling of heavy machines.
• Elderly.
• Reduce dosage gradually while withdrawing drug.