Benzathine benzylpenicillin-also known as benzathine penicillin G

Benzathine benzylpenicillin-also known as benzathine penicillin G

Penicillin G benzathine; Bicillin L-A; Benzatina bencilpenicilina; Benzathine benzylpenicilline; Benzathini benzylpenicillinum

Longacillin, Pencom, Pencom-LA, Penidure LA12, Penidure LA24, Penidure LA6

benzyl[2-(benzylazaniumyl)ethyl]azanium bis((2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate)

Inhibiting the bacterial cell wall synthesis

• 900 mg as a single dose for Treponemal infections and for Streptococcal pharyngitis as IM.
•  For the treatment of early syphilis:  1.8 g of single dose, usually as 2 injections in separate sites while as late syphilis: 1.8 g at wkly intervals for 3 consecutive weekk for Syphilis as IM.

Used to treat acute glomerulonephritis, respiratory tract infections, rheumatic fever and chorea, rheumatic heart disease, rheumatic heart disease, syphilis and other venereal diseases.

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; haemolytic anaemia; serum sickness-like reactions; interstitial nephritis; thrombocytopenia; neutropenia; convulsions; diarrhoea; antibiotic-associated colitis.

• Bacteriostatic drugs e.g. tetracyclines; chloramphenicol, other antibacterials;
• Anticoagulants.
• Probenecid prolongs T1/2 of benzathine benzylpenicillin.

Molecular weight

909.13

Molecular formula

C48H56N6O8S2

CAS number

1538-09-6

Precautions

• In very high doses had a risk of heart failure or neurotoxicity.
• Avoid contact, skin sensitization may occur.
• Avoid intrathecal route.
• Monitor serum potassium concentration, renal and haematological status.