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Betamethasone-Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders

Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases More

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Description

Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases

Generic Name

Betamethasone-Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders

Chemical names

Betadexamethasone; Celestone; Flubenisolone; Rinderon

Brand names

Becleren, ABC Derm, Acticard, Alcoderm, Aliderma, Avifun-N, Balderm, Basic Oint, BC-Zole DPS, BDM, Beclex-GM, Becmet-CG, Belar, Belar Forte, Ben, Belsone, Benicort, Bestowon, Benicort-N, Betacortril, Betacort, Betafoam, Be

IUPAC name

(1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0²,?.0¹¹,¹?]heptadeca-3,6-dien-5-one

Pharmacokinetics

  • Absorption: Oral
  • Distribution: Distributed throughout body tissues
  • Metabolism: Hepatic
  • Excretion: Urine

Actions

Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties.

Dosage/Dosage form

Apply as directed by physician.

Therapeutic uses

Topical use (cream, lotion and ointment): for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Foam (Topical use): used for the relief of the pruritic and inflammatory manifestations of corticosteroid-responsive dermatoses of the scalp. Systemic use: for the treatment of edocrine disorders, collagen diseases, rheumatic disorders, allergic states, dermatological diseases, hematologic disorders, ophthalmic diseases, neoplastic diseases, respiratory diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.

Adverse effects/Side effects

Sodium and fluid retention, potassium and calcium depletion. Muscle wasting, weakness, depression, osteoporosis. GI disturbances and bleeding, hirsutism, bruising. 

Interaction

·       Increased hyperglycaemia and hypokalaemia with thiazide diuretics.

·       Response to anticoagulants altered.

·       Increased incidence of peptic ulcer or GI bleeding with concurrent NSAIDs administration.

·       Dose of antidiabetics and antihypertensives needs to be increased.

·       Decreases serum conc of salicylates and antimuscarinic agents.

·       Enhanced effect in women taking oestrogens or oral contraceptives.

·       Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidone, barbiturates and rifampicin. 

Food Interactions: May be taken with food to decrease GI stress.

Contraindications

Hypersensitivity; systemic fungal or acute infections

Storage

Store below 25°C.

Information

Molecular weight

392.4611

Molecular formula

C22H29FO5

CAS number

378-44-9

Precautions

Uncontrolled diabetes, peptic ulcer, osteoporosis, psychosis, psychoneurosis, pregnancy and lactation. Hypertension, congestive heart failure, glaucoma, epilepsy, hypothyroidism, cirrhosis, ocular herpes simplex, ulcerative colitis, infants and children.