Bethanechol
2-[(Amino carbonyl) oxy]-N, N, N-trimethyl-1-propanaminium chloride
Urecholine
1-(trimethylazaniumyl) propan-2-yl carbamate
Distribution: Does not cross blood-brain barrier.
Actions: Bethanechol directly stimulates muscarinic receptors, causing increased intestinal motility and tone.
It also stimulates the muscles of the bladder (detrusor) whereas the trigone and sphincter are relaxed, causing expulsion of urine.
Adult: 10-50mg 3-4 times daily.
Oral
Bethanechol is used to stimulate the atonic bladder in urologic treatment, particularly in postpartum or postoperative, no obstructive urinary retention. Bethanechol may also be used to treat neurogenic atony as well as mega colon.
Adverse effects: Bethanechol causes the effects of generalized cholinergic stimulation. These include sweating, salivation, flushing, decreased blood pressure, nausea, abdominal pain, diarrhea, and bronchospasm.
Procainamide or quinidine: Antagonism of anticholinergic effects of bethanechol.
Cholinergic agents: Possible toxicity because of additive effects.
Tablets: 59° to 86°F
Injections: In between -4°F to 104°F.
196.68
C7H17ClN2O2
590-63-6
Urinary retention
