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Bleomycin-is a medication used to treat cancer.

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Bleomycin-is a medication used to treat cancer.

Bleomycin is a medication used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. More

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Description

Bleomycin is a medication used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others.

Generic Name

Bleomycin-is a medication used to treat cancer.

Chemical names

Bleomicina; Bleomycins; Bleomicin; Bleomycine; Bleomycinum

Brand names

Bledmax, Bleocare, Bleocel, Bleochem, Bleocin, Bleocip, Bleolem, Bleomycin, Bleonco, Bleosol, Bleostar-S, Bleotex, Lyoble, Naprobleo, Oil Bleo, Oncobleo.

IUPAC name

(3-{[2-(2-{2-[(2S,3R)-2-[(2S,3S,4R)-4-[(2S,3R)-2-({6-amino-2-[(1S)-1-{[(2S)-2-amino-2-carbamoylethyl]amino}-2-carbamoylethyl]-5-methylpyrimidin-4-yl}formamido)-3-[(3-{[4-(carbamoyloxy)-3,5-dihydroxy-6-(hydroxymethyl)oxan-2

Pharmacokinetics

  • Absorption: Oral
  • Distribution: 1% protein binding, crosses the placenta
  • Metabolism: Hepatic
  • Excretion: Urine

Actions

It is an antibiotic has an antitumor activity, inhibits the synthesis of DNA (deoxyribonucleic acid) selectively. The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. 

Dosage/Dosage form

The recommended dose is 0.25 to 0.5 units per kg once or twice in a week.

Therapeutic uses

Used to treat head and neck cancer, skin cancer, oral cavity cancer and lymphoma.

Adverse effects/Side effects

Fever, thrombophloebitis (injection). Acute anaphlyactoid reactions, hyperpyrexia. Rash, erthyema, pruritus, vesiculate, hyperkeratosis, nail changes, hyper pigmentation, alopecia, stomatitis, interstitial pnemonitis, pulmonary toxicity, fibrosis, cardiorespiratory collapse in patients with lymphoma.

Interaction

  • Elimination decreased by cisplatin.
  • Lomustine increases severity of leukopenia.
  • Decreases plasma levels of digoxin and Phenytoin.
  • Enhanced pulmonary toxicity in patients given with oxygen.

Contraindications

  • Hypersensitivity.
  • Severe pulmonary disease
  • Pregnancy and lactation.

Storage

Refrigerate at 2-8°C.

Information

Molecular weight

1415.552

Molecular formula

C55H84N17O21S3

CAS number

11056-06-7

Precautions

  • Pulmonary infection, preexisting pulmonary function impairment, renal impairment.
  • Elderly.
  • Discontinue treatment if chest x rays show infiltrates or breathlessness occurs.

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