Brimonidine-to treat open-angle glaucoma or ocular hypertension

Brimonidine is a drug used as eye drops under the brand names Alphagan and Alphagan-P to treat open-angle glaucoma or ocular hypertension, and as a gel, Mirvaso, for facial skin redness in rosacea.

Brimonidine-to treat open-angle glaucoma or ocular hypertension

Brimonidine; Bromoxidine; UK 14,304; Mirvaso

Alphagan, Alphagan-P, Alphagan-Z, Brimochek, Brimochek-T, Brimocom, Brimodin, Brimodin-LS,, Brimodin-P, Brimolol, Brimonist, Brimonist-TM, Brimopress, Brimosun-P, Combigan, Iobrim, Rimonid

5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers IOP by reducing aqueous humor production.

Instill 1 drop of a 0.2% solution bid-tid.

Used to treat open-angle glaucoma or ocular hypertension.

Oral dryness; fatigue or drowsiness; burning and stinging; conjunctival follicles, headache, blurring of vision; foreign body sensation, eyelid oedema, ocular allergic reactions, ocular pruritus, corneal staining or erosion, photophobia, eyelid erythema, ocular ache and pain, tearing; ocular dryness, upper respiratory symptoms; conjunctival oedema, dizziness, blepharitis, ocular irritation; GI symptoms; asthaenia; conjunctival blanching, abnormal vision and muscular pain.

• Possibility of an additive or potentiating effect with CNS depressants e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics.
• Caution when used with ophthalmic and systemic β-blockers, cardiac glycosides or antihypertensive drugs.
• TCAs can affect the metabolism and uptake of circulating amines.

Hypersensitivity. Patients receiving MAO inhibitor therapy

Store at 15-25°C

Molecular weight

292.135

Molecular formula

C11H10BrN5

CAS number

59803-98-4

Precautions

• Patients wearing soft contact lenses should wait for at least 15 min after instilling brimonidine tartrate before inserting soft contact lenses.
• CV disease.
• Renal or hepatic impairment.
• Use with caution in patients with depression, cerebral or coronary insufficiency, Reynaud’s phenomenon, orthostatic hypotension or thromboangitis obliterans.
• Pregnancy, lactation.