Bromocriptine- used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

Bromocriptine- used in the treatment of pituitary tumors, Parkinson's disease, hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.

Bromocryptine; Bromoergocriptine; Bromocriptin; Bromoergocryptine

B-Crip, Briptin, Brom, Bromogen, Bromotin, Criptal, Diacriptin, Diacriptin-M, Encript, Glucomind, Kripti, Ovucript, Parlodel, Polodyl, Proctinal, Semi-Brom, Sicriptin.

(4R,7R)-10-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-(propan-2-yl)-3-oxa-6,9-diazatricyclo[7.3.0.0²,?]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.0²,?.0¹²,¹?]hexadeca-1(16),2,9,12,14-pentaene-4-

Oral absorption with 90-96% protein binding, it undergoes first pass metabolism, excreted mainly via feces and urine.

It is a D2 and D3- dopamine agonist, acts by activating postsynaptic dopamine receptors in the nigrostriatal pathways and tuberoinfundibular. Bromocriptine also inhibits the prolactin secretion from the anterior pituitary and is used in the treatment of endocrinological and in prolactinoma disorders.

It comes as capsule or tablet.

Prescribed for the treatment of PD (Parkinson's disease), pituitary tumors, and neuroleptic malignant syndrome.

Nausea, vomiting, gastric haemorrhage (acromegaly), dizziness, headache, depression, drowsiness, postural hypotension, pleural effusion, nasal congestion, mania, and ataxia. High doses produce confusion, hallucinations, delirium, and psychosis.

• If given along with erythromycin bioavailability increased.
• Effects of antihypertensives may be potentiated.
• Alcohol reduces tolerance to bromocriptine and vice-versa.
• Avoid concurrent psychotropics.
•  Food reduces nausea caused by bromocriptine

• Breast carcinoma, hypersensitivity to ergot alkaloids, uncontrolled hypertension, severe ischaemic heart disease.
• Pregnancy and lactation.

Stored in an air tight container.

Molecular weight

654.595

Molecular formula

C32H40BrN5O5

CAS number

25614-03-3

Precautions

Increased risk of conception, patients with peptic ulcer, diabetes, diabetic retinopathy, impaired hepatic or renal function, pleuropulmonary signs and symptoms, history of psychosis, CV disease, dementia or concurrent antihypertensive therapy, ability to drive vehicles or operating machinery may be impaired.