Brotizolam- sedative-hypnotic thienotriazolodiazepine drug

Brotizolam is a sedative-hypnotic thienotriazolodiazepine drug which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.

Brotizolam- sedative-hypnotic thienotriazolodiazepine drug

Lendormin; Lendorm; Sintonal; 57801-81-7

4-bromo-7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,?]trideca-2(6),4,7,10,12-pentaene

250 mcg per day at bedtime, up to 2 weeks.

Treatment of Insomnia.

Drowsiness and lightheadedness, sedation, muscle weakness and ataxia; less frequently vertigo, headache, confusion, depression, slurred speech, changes in libido, tremor, urinary retention, visual disturbances, GI disturbances, amnesia and changes in salivation.

• Enhanced sedation or respiratory and cardiovascular depression with drugs with CNS depressant properties such drugs are antihistamines, antidepressants, antipsychotics, general anaesthitics, other hypnotics or sedatives, opioid analgesics and cisapride.
• Alcohol.
• Calcium-channel blockers; diaxozide; clonidine; disulfiram; diuretics; clozapine; moxonidine; nabitone; cimetidine, nitrates; esomeprazole and omeprazole; muscle relaxants; dopaminergics; lofexidine; hydralazine, antifungals; Minoxidil, nitroprusside; angiotensin II receptor antagonist; antiepileptics; βeta-blockers; antibacterials

• Preexisting CNS depression or coma, respiratory acute pulmonary insufficiency or depression, sleep apnoea; severe hepatic impairment;
• Pregnancy and lactation.
• Neonates.

Keep away from children.

Molecular weight

393.689

Molecular formula

C15H10BrClN4S

CAS number

57801-81-7

Precautions

• Chronic pulmonary insufficiency; elderly or debilitated patients; impaired liver or kidney function; muscle weakness, drowsiness may affect skilled tasks;
• Monitor cardio-respiratory function when used for deep sedation; history of alcohol or drug addiction, personality disorders or organic brain changes.
• Respiratory depression and hypotension with parenteral administration; this route should only be used when facilities for reversing respiratory depression are available. Dependence.