Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine. More
Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.
Buclizine-antihistamine and anticholinergic of the piperazine derivative
Buclizine; Histabuticine; Histabutizine; Histabutyzine; Buclifen
Longifene, Longifene SYR, Longifene-DA SYR, Longifene-DS
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
Oral absorption with hepatic metabolism.
It is a derivative of piperazine antihistamine with moderate sedative properties and antimuscarinic activity. It is used mainly for its antiemetic action and in the treatment of migraine in combination with analgesics.
The recommended dose range is 12.5 to 50 mg in divided doses. It comes as chewable tablet.
For the treatment of vomiting, nausea and dizziness and also used for the prophylaxis of motion sickness and vertigo.
Drowsiness, dizziness, incoordination; blurred vision; urinary retention; vomiting; rash; dry mouth; headache, nausea, epigastric pain, wt gain and diarrhoea.
Effect of alcohol, sedatives and other CNS depressants potentiated.
Hypersensitivity; neonates.
Store it at room temperature.
433.028
C28H33ClN2
82-95-1
Urinary retention; driving or operating machinery; open-angle glaucoma; prostatic hyperplasia, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment; pregnancy.
