Bupropion-used as an antidepressant and smoking cessation aid

Bupropion is a medication primarily used as an antidepressant and smoking cessation aid. It is marketed as Wellbutrin and Zyban among other trade names.

Bupropion-used as an antidepressant and smoking cessation aid

Amfebutamone; Amfebutamon; 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one; Amfebutamonum

Bupdep, Bupep, Bupisure, Bupron-SR, Bupron-XL, Ession-ER, Nicotex, Smoquit-SR, Zyban

2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one

Well absorbed

Bupropion, an antidepressant of the aminoketone class and a non-nicotine aid to smoking cessation, is chemically unrelated to selective serotonin re-uptake inhibitor, tetracyclic, tricyclic, or other known antidepressant agents. Bupropion is a relatively weak inhibitor of the neuronal uptake of serotonin, norepinephrine and dopamine. 

Oral route

• Initially, 100 mg bid increased to 100 mg tid after 3 days if necessary to treat depression.
• Initially, 150 mg once daily for 6 days then increased to 150 mg bid used for smoking cessation.

For the treatment of depression and as aid to smoking cessation.

Facial oedema; nausea, dry mouth, constipation, diarrhoea, anorexia; mouth ulcer; thirst; myalgia, arthralgia; insomnia, abnormality, dream, anxiety, dizziness, disturbed concentration, nervousness, dysphoria; tremor, rhinitis, increased cough, pharyngitis, sinusitis; dyspnoea, epistaxis, agitation, insomnia, tremor, headache, weight loss, vomiting, skin rash. Stevens-Johnson syndrome.

• Concurrent use with MAO inhibitors may cause acute toxicity symptoms and increased risk of fatality.
• Reduced hepatic clearance with fluoxetine.
• Neuroleptics, lithium and TCAs, benzodiazepine, alcohol, drugs that lower seizure threshold.
• Increased risk of side effects when co-admin with levodopa.
• Caution when administering with agents that will affect hepatic drug metabolizing enzymes.
• Increased risk of toxicity when used with ritonavir.

Epilepsy; eating disorders (e.g. bulimia or anorexia nervosa); hypersensitivity

Store at 15-25°C.

Molecular weight

239.741

Molecular formula

C13H18ClNO

CAS number

34911-55-2

Precautions

• History of seizure disorders, bipolar disorders
• Renal or hepatic impairment.
• MI or unstable heart disease
• Pregnancy
• Monitor BP before and after treatment
• May impair ability to drive and operate machinery.
• Avoid use within 2 weeks of MAO inhibitor withdrawal.