Buspirone, brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder. It is also commonly used to augment antidepressants in the treatment of depression. More
Buspirone, brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder. It is also commonly used to augment antidepressants in the treatment of depression.
Buspirone-an anxiolytic drug that is primarily used to treat generalized anxiety disorder.
Ansial; Buspironum; Buspirona
Buscalm, Buson, Buspidac, Buspin, Supiron-B, Tamspar
8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione
Buspirone will suppress serotonergic activity is while noradrenergic and dopaminergic cell firing is enhanced, it binds to 5-HT type 1A serotonin receptors on postsynaptic neurons and on presynaptic neurons in the dorsal raphe, in the hippocampus thus inhibiting the rate of 5-HT-containing neurons in the dorsal raphe. It also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of neither neither brain where nor are epinephrine cell bodies found in high concentration.
Initially, 5 mg bid/tid increased by 5-mg increments at intervals of 2-3 days.
In short term management of anxiety
Dizziness, nausea, headache, nervousness, lightheadedness, paraesthesia, excitement, sleep disturbances, tinnitus, chest pain, nasal congestion, sore throat. Less sedation and lower potential for dependence compared to other anxiolytics.
Store at 15-30°C
385.5031
C21H31N5O2
36505-84-7
