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Echothiophate

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Description

Generic Name

Echothiophate

Chemical names

Phospholine, Ecothiopatum

Brand names

Phospholine Iodide

IUPAC name

diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate

Pharmacokinetics

Absorbed systemically

Actions

Echothiophate Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echothiophate iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiating of accommodation.

 

Dosage/Dosage form

Ophthalmic medication

Therapeutic uses

Used in the treatment of glaucoma

Adverse effects/Side effects

Blurred vision, eye pain

Interaction

Echothiophate may increase the bradycardic activities of Alprenolol, Acebutolol.

Contraindications

Do not use for tonometric glaucoma

Storage

Room temperature

Information

Molecular weight

256.321 g/mol

Molecular formula

C9H23NO3PS

CAS number

6736-03-4

Precautions