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Gabapentin

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Gabapentin

Gabapentin, marketed under the brand name Neurontin among others, is a medication used to treat epilepsy, neuropathic pain, hot flashes, and restless leg syndrome. In epilepsy it may be used for those with partial seizures. More

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Description

Gabapentin, marketed under the brand name Neurontin among others, is a medication used to treat epilepsy, neuropathic pain, hot flashes, and restless leg syndrome. In epilepsy it may be used for those with partial seizures.

Generic Name

Gabapentin

Chemical names

Gabapentin; Neurontin; Gabapentine; 1-(Aminomethyl)cyclohexaneacetic acid; 2-[1-(aminomethyl)cyclohexyl]acetic acid

Brand names

Alcobal, Alnacob-G, Armet-G, Asmeth-G, Bigvin Forte, Bigvin Tab, Capin-G, Chiny-Gp, Cobagen, Cobanerve-G, Cobsa-G, Cymevene, Doloneuron, Electa-Gp, Encentin, Encentin Plus, Encentin-AM, Encentin-M, Evatin-M, G-Care, G-Neuro, Gaba, Gaba-Hosit, Gaba-M, Gaba-Mc, Gabacap, Gabacent, Gabaciz, Gabaciz-M, Gabacure, Gabafact, Gabafine, Gabalept, Gabamin, Gabaneuron, Gabaneuron-SR, Gabanez-M, Gabantin, Gabantin Forte, Gabantin Plus, Gabapee, Gabapin, Gabapin-Me, Gabapin-NT, Gabapin-SR, Gabarace-M, Gabastar-M, Gabasun, Gabata, Gabata Plus

IUPAC name

2-[1-(aminomethyl)cyclohexyl]acetic acid

Pharmacokinetics

Oral absorption

Actions

It is an analog of GABA, used as an anticonvulsant drug to treat ALS (amyotrophic lateral sclerosis), partial seizures, and painful neuropathies. Gabapentin has high lipid solubility, is not metabolized by the liver, has no protein binding, and doesn't possess the usual drug interactions.

Dosage/Dosage form

Oral

Therapeutic uses

It is anticonvulsant, prescribed for epilepsy and post herpetic neuralgia.

Adverse effects/Side effects

Somnolence, dizziness, ataxia, weakness, paraesthesia, fatigue, headache; nystagmus, diplopia; nausea, vomiting, wt gain, dyspepsia; rhinitis; tremor; leucopenia; altered LFTs; Stevens-Johnson syndrome.

Interaction

  • Absorption reduced with antacids.
  • Cimetidine may reduce gabapentin clearance. 

Contraindications

Hypersensitivity. Lactation

Storage

Store at 20-25 ?

Information

Molecular weight

171.2368

Molecular formula

C9H17NO2

CAS number

60142-96-3

Precautions

  • Discontinuation or transfer from other antiepileptics, history of psychotic illness; renal impairment; pregnancy.
  • Gabapentin should not be discontinued abruptly after long term use.
  • Abrupt or over rapid withdrawal may provoke a withdrawal syndrome similar to alcohol or benzodiazepine withdrawal. 

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