Galantamine

Galantamine is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments, in particular those of vascular origin.

Galantamine

Galanthamine; Galantamine; Lycoremine; (-)-Galanthamine

Galamer

(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0¹,¹².0?,¹?]heptadeca-6(17),7,9,15-tetraen-14-ol

Hepatic metabolism

Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. It is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. An early Pathophysiological feature of Alzheimer's disease associated with memory loss and cognitive deficits are a deficiency of acetylcholine as a result of selective loss of cholinergic neurons in the cerebral cortex, nucleus basalis, and hippocampus. Galantamine is postulated to exert its therapeutic effect by enhancing cholinergic function. 

The recommended dose is 4mg every 12 hours PO.

For the treatment of mild to moderate dementia of the Alzheimer's type. 

Anuria, tarry stools, chest pain, bradycardia, malena, weakness, polydipsia, fatigue, weight loss, headache, nausea and anorexia.

Galantamine may interact with other drugs such as methscopolamine, belladonna, mepenzolate, ketoconazole, glycopyrrolate, dicyclomine, clinidium, atropine and propantheline.

Hypersensitivity.

Store at 20-25°C.

Molecular weight

287.3535

Molecular formula

C17H21NO3

CAS number

357-70-0

Precautions

• Galantamine is contraindicated in patients with urination problems, hepatic disorders, seizures, arrhythmia, renal problems, GI bleeding and COPD.
• Do not operate heavy machineries or do not drive vehicles.
• Galantamine may impair cognitive and thinking abilities.