Gemifloxacin

Gemifloxacin mesylate is an oral broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia.

Gemifloxacin

Gemifloxacin; Gemifioxacin; Factive; Gemifloxacin [INN]

Adgem, Curegem, EG1, Floxigem, G-Cin, G-Floren, Gametop, Gamibit, Gamiflox, Gembax, Gemberg, Gemexin, Gemez, Gemibid, Gemicef, Gemidac, Gemif, Gemifix, Geminex, Gemistar, Gemitab, Gemsharp, Gemven, Gemvig, Gex, GQ-320, Graptor, J-Cin, Kinocin, Le-Gami, Quinhext, Topgem, Zemi

7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Rapidly absorbed from the gastrointestinal tract

Gemifloxacin is a quinolone/fluoroquinolone antibiotic. Gemifloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required replicating one DNA double helix into two. Gemifloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

160 mg every 24 hr.

For the treatment of bacterial infection caused by susceptible strains such as S. pneumoniae, H. influenzae, H. parainfluenzae, or M. catarrhalis, S. pneumoniae (including multi-drug resistant strains [MDRSP]), M. pneumoniae, C. pneumoniae, or K. pneumoniae.

Diarrhoea, nausea, vomiting; headache, dizziness; rash, urticaria. May cause elevation of liver enzymes

• May potentiate QT prolongation when used with drugs that affect the QT interval e.g. cisapride, erythromycin, antipsychotics and TCAs.
• Bioavailability is lower if co administered with multivalent cation preparations e.g. aluminum, magnesium, or iron salts.
• Increased plasma levels when used with probenecid.
• May increase prothrombin time when used with warfarin or its derivatives.

Hypersensitivity. Patients receiving class IA or III antiarrhythmic.

Store between 15-30 ?.

Molecular weight

389.3809

Molecular formula

C18H20FN5O4

CAS number

175463-14-6

Precautions

• History of prolongation of QT interval, uncorrected electrolyte disorders, CNS diseases such as epilepsy.
• Maintain adequate hydration.
• Increased risk of rash when treatment duration is prolonged.
• Children <18 yr. Pregnancy, lactation.