Glatiramer acetate is an immunomodulator drug currently used to treat multiple sclerosis. It is a random polymer of four amino acids found in myelin basic protein, namely glutamic acid, lysine, alanine, and tyrosine. More
Glatiramer acetate is an immunomodulator drug currently used to treat multiple sclerosis. It is a random polymer of four amino acids found in myelin basic protein, namely glutamic acid, lysine, alanine, and tyrosine.
Glatiramer
Glatiramer; Glat copolymer; Tgal copolymer; Copolymer i; COP 1
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Glatiramer acetate was originally designed to mimic a protein in myelin, called myelin basic protein, with the intention of inducing EAE (an animal model of MS). There is some evidence that Glatiramer acetate converts the body's immune response from a Th1 type to a Th2 one, promotes suppressor T cells or acts as an altered peptide ligand. Studies in animals and in vitro systems suggest that upon its administration, glatiramer acetate-specific suppressor T-cells are induced and activated in the periphery.
The recommended dose is 20 mg/kg as SC.
For reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.
Rash, chest pain, palpitation, increase in weight, back pain, skin cancer.
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Glatiramer is contraindicated in patients with allergy to mannitol or Glatiramer.
Store at 20-25°C.
7000.0 Da (range 5000-9000)
C254H422N70O72
147245-92-9
Avoid excess dosage.
