Gliclazide

Gliclazide, sold under the brand name Diamicron among others, is an anti-diabetic medication used to treat diabetes mellitus type 2. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth.

Gliclazide

Gliclazide; Glimicron; Diamicron; Nordialex

Alglid, Aviglic, Azukon, Azukon-MR, Cgcron, Claz-OD, Comzid, D-Clic, Debgone, Diabend, Diabend-MR, Diabic, Diagli, Dialaz, Diamicron, Diamicron-XR, Dianorm, Dianorm-OD, Diaob, Diatrol, Diazide, Dibend MR, Dizide, Euclide, Fordib, Glatix, Glazid, Glic, Glican, Glicla, Gliclafin, Gliclan, Gliclatan, Gliclaz, Glicron, Gliden-MR, Glidiet-80, Glisafe, Glital, Glityx, Glix, Glix-MR, Gliza, Glizid, Glucoact, Glucofit, Glucoril, Glucozid, Glurib, Glutide-CR

1-(4-methylbenzenesulfonyl)-3-{octahydrocyclopenta[c]pyrrol-2-yl}urea

Oral absorption with 94% protein binding, extensively metabolized by liver.

Gliclazide is a second generation sulphonylurea which acts as a hypoglycemic agent. It stimulates β cells of the islet of Langerhans in the pancreas to release insulin. It also enhances peripheral insulin sensitivity. Overall, it potentiates insulin release and improves insulin dynamics.

Initially starts with 160 mg daily in 2 divided doses. May go up to 320 mg daily in two divided doses as PO. 

For the treatment of NIDDM in conjunction with diet and exercise.

GI disturbances, skin reaction, leucopenia, thrombocytopenia, agranulocytosis, haemolytic anaemia, cholestatic jaundice, vomiting, diarrhoea, gastritis, increased transaminases.

• Nausea and flushing with alcohol.
• Hypoglycaemic effect increased by salicylates, phenylbutazone, clofibrate, sulphonamides, oral anticoagulants and MAOIs.
• Hypoglycaemic effect diminished by barbiturates, rifampicin, alcohol, diazoxide, diuretics, corticosteroids, oestrogens, β-blockers and sympathomimetic drugs; dose adjustment may be required.

Type 1 DM, diabetes complicated with ketoacidosis; hypersensitivity; severe renal and hepatic impairment. Pregnancy and lactation.

Store it at room temperature.

Molecular weight

323.411

Molecular formula

C15H21N3O3S

CAS number

21187-98-4

Precautions

• Monitor blood glucose concentration.
• May require insulin during metabolic stress.
• Care when transferring from combination therapy.
• Increased risk of severe hypoglycaemia in elderly, debilitated patients, patients with hepatic or renal impairment.
• Risk of hypogylcaemia when caloric intake is deficient, after strenuous exercise, when taken with ethanol or when >1 antidiabetic drug is used.