Glycopyrronium bromide

Glycopyrronium bromide is a medication of the muscarinic anticholinergic group. It does not cross the blood–brain barrier and consequently has no to few central effects.

Glycopyrronium bromide

Glycopyrronium bromide; Glycopyrrolate bromide; 596-51-0; Robinul

Glyco-P, Glycolate, Glycopyrrolate, Glyprolate, Licolate, Lycolate, Myo-Pyrolate, Pyrolate, Pyrolin, Vagolate

(3S)-3-{[(2R)-2-cyclopentyl-2-hydroxy-2-phenylacetyl]oxy}-1,1-dimethylpyrrolidin-1-ium

• Rapidly absorbed (1-2 minutes) after intravenous injection
• Excreted Via bile and urine.

Glycopyrrolate decreases acid secretion in the stomach. Hence it can be used for treating ulcers in the stomach and small intestine, in combination with other medications. Glycopyrrolate injection serves as a preoperative antimuscarinic operation in anesthesia, that reduces tracheobronchial, salivary, and pharyngeal secretions, as well as decreases the acidity of gastric secretions blocks cardiac vagal inhibitory reflexes during intubation

NA

For use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation. Also used to treat chronic obstructive pulmonary disease (COPD).

Xerostomia; loss of taste, nausea, vomiting, constipation, reduced sweating; urinary hesitancy and retention; blurred vision; cycloplegia; increased ocular tension; tachycardia; palpitation; headache, anxiety, bloated feeling, impotence, skin reactions.

• Decreases levodopa effects. Effects may be enhanced by using drugs with antimuscarinic properties or MAOIs concurrently. May antagonise the GI effects of cisapride, metoclopramide and dompeidone.
• IV admin in the presence of cyclopropane anesth can result in ventricular arrhythmias.

• Hypersensitivity.
• Paralytic ileus; Glaucoma; obstructive GI diseases; obstructive uropathy; pyloric stenosis; intestinal atony; myasthenia gravis.
•  Unstable CV status in acute haemorrhage.
• Injectable not recommended in new borns ≤1 mth if benzyl alcohol is present in the preparation.

Store at 20-25°C.

Molecular weight

318.436

Molecular formula

C19H28NO3

CAS number

740028-90-4

Precautions

Pregnancy, lactation. CV disease, hyperthyroidism, hepatic or renal impairment. Enlarged prostate, diarrhoea, fever. May cause ileus or megacolon in patients with ulcerative colitis. Children and elderly.